TY - JOUR AU - Wang, Xin PY - 2018/05/22 Y2 - 2024/03/28 TI - Analysing Trends of Guillain-Barre Syndrome (GBS)and Dengue cases in Hong Kong JF - Online Journal of Public Health Informatics JA - OJPHI VL - 10 IS - 1 SE - Public/ Population Health Surveillance Practice DO - 10.5210/ojphi.v10i1.8685 UR - https://ojphi.org/ojs/index.php/ojphi/article/view/8685 SP - AB - <div><table width="640" border="0"><tbody><tr><td><p><span class="pagecontents"><span style="font-size: small;"><strong>Objective: </strong></span></span></p><p><span class="pagecontents"><span style="font-size: small;"><strong></strong>To study the trends of GBS and dengue in Hong Kong, the ecological associations between GBS, dengue, and local meteorological factors. To examine the non-stationary oscillating association among these factors.<br /><strong><br />Introduction: </strong></span></span></p><p><span class="pagecontents"><span style="font-size: small;"><strong></strong>Guillain-Barre Syndrome (GBS) is a severe paralytic neuropathy associated with virus infections such as Zika virus and Chikungunya virus. There were also case reports of dengue fever preceding GBS. With the aim to understand the mechanisms of GBS and dengue outbreaks, this ecological study investigates the relationships between GBS, dengue,<br />meteorological factors in Hong Kong and global climatic factors from January 2000 to June 2016.<br /><strong><br />Methods: </strong></span></span></p><p><span class="pagecontents"><span style="font-size: small;"><strong></strong>The correlations between GBS, dengue, Multivariate El Nino Southern Oscillation Index (MEI) and local meteorological data were explored by Spearman's Rank correlations and cross-correlations. Three Poisson regression models were fitted to identify non-linear associations among GBS, dengue and MEI. Cross wavelet analyses were applied to infer potential non-stationary oscillating associations among GBS, dengue and MEI.<br /><strong><br />Results: </strong></span></span></p><p><span class="pagecontents"><span style="font-size: small;"><strong></strong>We found a substantial increasing of local GBS and dengue cases (mainly imported) in recent year in Hong Kong. The seasonalities of GBS and dengue are different, in particular, GBS is low while dengue is high in the summer. We observed weak but significant correlations between GBS and local meteorological factors. MEI could explain over 17% of dengue's variations based on Poisson regression analyses. We report a possible non-stationary oscillating association between dengue fever and GBS cases in Hong Kong.<br /><strong><br />Conclusions: </strong></span></span></p><p><span class="pagecontents"><span style="font-size: small;"><strong></strong>We report increasing patterns of both local GBS cases and imported dengue cases in Hong Kong, and investigate the possible mechanism behind these patterns.This study has led to an improved understanding about the timing and ecological relationships between MEI, GBS and dengue.</span></span></p></td></tr></tbody></table></div> ER -