Population-based cancer registration is not common practice in developing countries. Ghana's first PBCR, the Kumasi Cancer Registry was established in 2012. We review data from the registry from 2012 to 2014. Females accounted for the majority (64.2%) of the 1,078 cases of cancer were recorded. Breast (35.1%), Cervix (23.7%), Ovary (7.9%), Liver (3.8%) and Endometrium (3.2%) were the top five cancers among females. Among males, the commonest cancers were Liver (21.8%), Prostate (17.9%), Stomach (4.1%), Lung (3.4%) and Bone marrow (2.9%). Histology was the basis of diagnosis for 58.7%. There is the need to establish more such registries in Ghana.
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